The Beneficial Effect of Salicornia herbacea Extract and Isorhamnetin-3-O-Glucoside on Obesity

Salicornia herbacea is a halophyte indigenous to marine coastal areas and salt fields has been used as traditional remedy for diarrhea, abdominal pain, constipation, indigestion. Its component isorhamnetin-3-O-glucoside (IR3G) may have antioxidant, anti-inflammatory, anti-adipogenic properties. In the present study, we aimed investigate anti-obesity effect of S. extract IR3G on mouse 3T3-L1 adipocytes db/db obesity mice. inhibited lipase in concentration-dependent manner. Oil Red O staining disclosed that significantly suppressed lipid accumulation adipogenesis also expression C/EBPα adipocytes. experiments using mice, administering limited body weight gain reduced feed efficiency adipose tissue weight. Moreover, analyzing blood triglycerides, total cholesterol, high-density lipoprotein, low-density it was confirmed LDL decreased cholesterol slightly by extract. However, there no significant change changes levels leptin adiponectin. Taken together, these results suggest inhibit suppressing pro-adipogenic transcription factors preadipocytes prevent regulating profile well tissue.